{{Title text: Check it out--when I tug the C-terminal tail, the binding tunnel squeezes!}} [[Man and woman talking]] Man: What do you do? Woman: I make software that predicts how proteins will fold. [[Same scene layout, second panel]] Man: Is that a hard problem? Woman: Someone may someday find a harder one. [[Same scene layout, third panel]] Man: Why is it so hard? Woman: Have you ever made a folded paper crane? Man: Yeah. [[Same scene layout, fourth panel]] Woman: Imagine figuring out the folds to make an actual living crane. Man: ... just folds? Can I make cuts? Woman: If you can fold a protease enzyme.